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When and how is LIVMARLI taken?

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liquid medicine
Taken approximately
before the first
meal of the day
Take medicine by mouth
Oral dosing dispenser
directly from measuring
device delivered with
your medicine
A household
tablespoon or teaspoon
Do not use household teaspoon/tablespoon
is not an accurate
measuring device

What happens if a dose is missed?

  • If you miss a dose within 12 hours of the time you normally take it, take LIVMARLI as soon as possible
  • If a dose is missed by more than 12 hours, skip the dose and continue your original dosing schedule the next day

For more information, please read the full Instructions for Use.

How should you store LIVMARLI?

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Store LIVMARLI at room temperature between

68 °F and 77 °F

(20 °F and 25 °F)


Properly dispose of any unused LIVMARLI

45 Days

after first opening of bottle


Always store LIVMARLI with the

cap on

the bottle

livmarli bottle

Keep LIVMARLI and all medicines out of reach of children.

Liver League kids


Be a Know-It-All

What should you know when taking LIVMARLI?

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When starting a medication, especially for a rare liver disease such as Alagille syndrome, it’s important to talk to your or your child’s doctor so they can help you better understand what to expect.

Doctor discussion

Here are a few things to discuss with your doctor when starting LIVMARLI:

Don’t stop or change the dose on your own without talking to your doctor first.

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Enroll in Mirum Access
Plus (MAP)

Receive support for every step of your LIVMARLI treatment.

Learn How to Enroll

Survey the Battlefield

Learn about the results of LIVMARLI in the battle against the itch in Alagille syndrome.

See LIVMARLI in Action
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LIVMARLI is a prescription medicine used to treat cholestatic pruritus (itch) in patients with Alagille syndrome 1 year of age and older. It is not known if LIVMARLI is safe and effective in children under 1 year of age or in adults 65 years and older.

Important Safety Information

What are the possible side effects 

LIVMARLI can cause serious side effects, including:

Changes in liver tests. Changes in certain liver tests are common in patients with Alagille syndrome but may worsen during treatment with LIVMARLI. These changes may be a sign of liver injury and can be serious. Your health care provider should do blood tests before starting and during treatment to check your liver function. Tell your health care provider right away if you get any signs or symptoms of liver problems, including:

  • nausea or vomiting
  • skin or the white part of the eye turns yellow
  • dark or brown urine
  • pain on the right side of the stomach (abdomen)
  • loss of appetite

Stomach and intestinal (gastrointestinal) problems. LIVMARLI can cause stomach and intestinal problems, including diarrhea, stomach pain, and vomiting during treatment. Tell your health care provider right away if you have any of these symptoms more often or more severely than normal for you.

A condition called Fat-Soluble Vitamin (FSV) Deficiency caused by low levels of certain vitamins (vitamins A, D, E, and K) stored in body fat. FSV deficiency is common in patients with Alagille syndrome but may worsen during treatment. Your health care provider should do blood tests before starting and during treatment.

Other common side effects reported during treatment were bone fractures and gastrointestinal bleeding.

Tell your health care provider about all medicines that you take. LIVMARLI may affect the way some other medicines work, and some other medicines may affect the way LIVMARLI works. If you take a medicine that lowers cholesterol by binding bile acids, such as cholestyramine, colesevelam, or colestipol, take it at least 4 hours before or 4 hours after you take LIVMARLI.

LIVMARLI is taken by mouth, 1 time each day, 30 minutes before the first meal of the day. Be sure to use the provided oral dosing dispenser to accurately measure the dose of medicine.

These are not all of the possible side effects of LIVMARLI. Call your health care provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see Patient Information: English | Español