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When and how is LIVMARLI taken?


liquid medicine
Taken approximately
before a meal
in the morning
Take medicine by mouth
Oral dosing dispenser
directly from measuring
device delivered with
your medicine
A household
tablespoon or teaspoon
Do not use household teaspoon/tablespoon
is not an accurate
measuring device

What happens if a dose is missed?

  • If you miss a dose within 12 hours of the time you normally take it, take LIVMARLI as soon as possible
  • If a dose is missed by more than 12 hours, skip the dose and continue your original dosing schedule the next day

For more information, please read the full Instructions for Use.

How should you store LIVMARLI?


Store unopened LIVMARLI at room temperature between

68 °F and 77 °F

(20 °C and 25 °C)


Properly dispose of any unused LIVMARLI

100 days

after first opening of bottle


After opening the LIVMARLI bottle,

store below 86 °F (30 °C)—once opened, the

bottle may be refrigerated if desired

livmarli bottle

Keep LIVMARLI and all
medicines out of reach of children

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Be a Know-It-All

What should you know when taking LIVMARLI?

When starting a medication, it’s important to talk to your or your child's doctor so they can help you better understand what to expect.

Doctor discussion

Here are a few things to discuss with your doctor when starting LIVMARLI:

Don’t stop or change the dose on your own without talking to your doctor first.


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Lower Costs Within Reach

Mirum Access Plus works closely with your doctor and insurance plan to help facilitate coverage for LIVMARLI.

Learn How to Enroll

Survey the Battlefield

Learn about the results of LIVMARLI in the battle against the itch in Alagille syndrome.

See LIVMARLI in Action
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LIVMARLI is a prescription medicine used to treat cholestatic pruritus (itch) in patients who are 3 months of age and older with Alagille syndrome.

It is not known if LIVMARLI is safe and effective in children with Alagille syndrome who are under 3 months of age. It is not known if LIVMARLI is safe and effective in adults who are 65 years of age and older.

Important Safety Information

What are the possible side effects 

  • Liver injury. Changes in certain liver tests are common in patients but may worsen during treatment with LIVMARLI. These changes may be a sign of liver injury and can be serious. Your health care provider should do blood tests and physical exams before starting and during treatment to check your liver function. Tell your health care provider right away if you get any signs or symptoms of liver problems, including:
    • nausea or vomiting
    • your skin or the white part of your eye turns yellow
    • dark or brown urine
    • pain on the right side of your stomach (abdomen)
    • fullness, bloating, or fluid in your stomach area (ascites)
    • loss of appetite
    • bleeding or bruising more easily than normal, including vomiting blood
  • Stomach and intestinal (gastrointestinal) problems. LIVMARLI can cause stomach and intestinal problems, including diarrhea and stomach pain during treatment. Diarrhea can also cause the loss of too much body fluid (severe dehydration). Your health care provider may advise you to monitor for new or worsening stomach problems, including stomach pain, diarrhea, blood in your stool, or vomiting. Tell your health care provider right away if you have any new or worsening signs or symptoms of stomach and intestinal problems, including:
    • diarrhea
    • more frequent bowel movements than usual
    • stools that are black, tarry, or sticky, or have blood or mucous
    • severe stomach-area pain or tenderness
    • vomiting
    • urinating less often than usual
    • dizziness
    • headache
  • A condition called Fat-Soluble Vitamin (FSV) Deficiency caused by low levels of certain vitamins (vitamin A, D, E, and K) stored in body fat. FSV deficiency is common in patients with Alagille syndrome but may worsen during treatment. Your health care provider should do blood tests before starting and during treatment, and may monitor for bone fractures and bleeding, which are common side effects.

Tell your health care provider about all medicines that you take, as LIVMARLI may interact with other medicines. If you take a medicine that lowers cholesterol by binding bile acids, such as cholestyramine, colesevelam, or colestipol, take it at least 4 hours before or 4 hours after you take LIVMARLI.
Your health care provider may change your dose, or temporarily or permanently stop treatment if you have certain side effects.

LIVMARLI is taken by mouth, 1 time each day, 30 minutes before a meal in the morning. Be sure to use the provided oral dosing dispenser to accurately measure the dose of medicine.

These are not all of the possible side effects of LIVMARLI. For more information, ask your health care provider or pharmacist. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.