Results with

The goal of LIVMARLI is to provide lasting itch relief for patients with Alagille syndrome who are 1 year of age and older.

Once-daily LIVMARLI is the first medicine to provide meaningful, long-lasting improvements in itchiness for patients with Alagille syndrome.

Will LIVMARLI work right away?

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LIVMARLI can work within weeks

LIVMARLI can work within weeks

Improvement in itch may be felt as early as 3 weeks after starting treatment.


How well does LIVMARLI work?

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Patients with Alagille syndrome were treated with LIVMARLI in a 4-year clinical study. During that time, many patients taking LIVMARLI experienced significantly less itchiness.

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During the first year of treatment with once-daily LIVMARLI, more than 80% of patients experienced less itchiness than they felt at the start of treatment.


Patients who continued to take LIVMARLI after the first year (as part of the long-term part of the clinical study) experienced minimal to no itch for the vast majority of days on treatment.

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Throughout the first year of the clinical study, the number of days with minimal to no itch continued to increase for patients taking LIVMARLI.


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Talk to Your Doctor About LIVMARLI

Talk to Your Doctor About LIVMARLI

Get the conversation started about whether LIVMARLI is right for you or your child.

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LIVMARLI is a prescription medicine used to treat cholestatic pruritus (itch) in patients with Alagille syndrome 1 year of age and older. It is not known if LIVMARLI is safe and effective in children under 1 year of age or in adults 65 years and older.

Important Safety Information

What are the possible side effects 

LIVMARLI can cause serious side effects, including:

Changes in liver tests. Changes in certain liver tests are common in patients with Alagille syndrome but may worsen during treatment with LIVMARLI. These changes may be a sign of liver injury and can be serious. Your health care provider should do blood tests before starting and during treatment to check your liver function. Tell your health care provider right away if you get any signs or symptoms of liver problems, including:

  • nausea or vomiting
  • skin or the white part of the eye turns yellow
  • dark or brown urine
  • pain on the right side of the stomach (abdomen)
  • loss of appetite

Stomach and intestinal (gastrointestinal) problems. LIVMARLI can cause stomach and intestinal problems, including diarrhea, stomach pain, and vomiting during treatment. Tell your health care provider right away if you have any of these symptoms more often or more severely than normal for you.

A condition called Fat-Soluble Vitamin (FSV) Deficiency caused by low levels of certain vitamins (vitamins A, D, E, and K) stored in body fat. FSV deficiency is common in patients with Alagille syndrome but may worsen during treatment. Your health care provider should do blood tests before starting and during treatment.

Other common side effects reported during treatment were bone fractures and gastrointestinal bleeding.

Tell your health care provider about all medicines that you take. LIVMARLI may affect the way some other medicines work, and some other medicines may affect the way LIVMARLI works. If you take a medicine that lowers cholesterol by binding bile acids, such as cholestyramine, colesevelam, or colestipol, take it at least 4 hours before or 4 hours after you take LIVMARLI.

LIVMARLI is taken by mouth, 1 time each day, 30 minutes before the first meal of the day. Be sure to use the provided oral dosing dispenser to accurately measure the dose of medicine.

These are not all of the possible side effects of LIVMARLI. Call your health care provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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